COVID-19, asthma, and biological therapies: What we need to know.
Identifieur interne : 001464 ( Main/Exploration ); précédent : 001463; suivant : 001465COVID-19, asthma, and biological therapies: What we need to know.
Auteurs : Mário Morais-Almeida [Portugal] ; Rita Aguiar [Portugal] ; Bryan Martin [États-Unis] ; Ignacio J. Ansotegui [Espagne] ; Motohiro Ebisawa [Japon] ; L Karla Arruda [Brésil] ; Marco Caminati [Italie] ; Giorgio Walter Canonica [Italie] ; Tara Carr [États-Unis] ; Geoffrey Chupp [États-Unis] ; Jonathan Corren [États-Unis] ; Ignacio Dávila [Espagne] ; Hae-Sim Park [Corée du Sud] ; Nicola A. Hanania [États-Unis] ; Lanny Rosenwasser [États-Unis] ; Mario Sánchez-Borges [Venezuela] ; J Christian Virchow [Allemagne] ; Anahí Yá Ez [Argentine] ; Jonathan A. Bernstein [États-Unis] ; Luis Caraballo [Colombie] ; Yoon-Seok Chang [Corée du Sud] ; Manana Chikhladze [Géorgie (pays)] ; Alessandro Fiocchi [Italie] ; Sandra N. González-Diaz [Mexique] ; Luciana Kase Tanno [France] ; Michael Levin [Afrique du Sud] ; Jose Ant Nio Ortega-Martell [Mexique] ; Giovanni Passalacqua [Italie] ; David B. Peden [États-Unis] ; Philip W. Rouadi [Liban] ; James L. Sublett [États-Unis] ; Gary W K. Wong [Hong Kong] ; Eugene R. Bleecker [États-Unis]Source :
- The World Allergy Organization journal [ 1939-4551 ] ; 2020.
Abstract
Managing patients with severe asthma during the coronavirus pandemic and COVID-19 is a challenge. Authorities and physicians are still learning how COVID-19 affects people with underlying diseases, and severe asthma is not an exception. Unless relevant data emerge that change our understanding of the relative safety of medications indicated in patients with asthma during this pandemic, clinicians must follow the recommendations of current evidence-based guidelines for preventing loss of control and exacerbations. Also, with the absence of data that would indicate any potential harm, current advice is to continue the administration of biological therapies during the COVID-19 pandemic in patients with asthma for whom such therapies are clearly indicated and have been effective. For patients with severe asthma infected by SARS-CoV-2, the decision to maintain or postpone biological therapy until the patient recovers should be a case-by-case based decision supported by a multidisciplinary team. A registry of cases of COVID-19 in patients with severe asthma, including those treated with biologics, will help to address a clinical challenge in which we have more questions than answers.
DOI: 10.1016/j.waojou.2020.100126
PubMed: 32426090
PubMed Central: PMC7229954
Affiliations:
- Afrique du Sud, Allemagne, Argentine, Brésil, Colombie, Corée du Sud, Espagne, France, Géorgie (pays), Hong Kong, Italie, Japon, Liban, Mexique, Portugal, Venezuela, États-Unis
- Arizona, Californie, Caroline du Nord, Connecticut, Kentucky, Languedoc-Roussillon, Latium, Occitanie (région administrative), Ohio, Région capitale de Séoul, Texas, État de São Paulo
- Chapel Hill (Caroline du Nord), Montpellier, Rome, Sha Tin, São Paulo, Séoul
- Université chinoise de Hong Kong, Université de Caroline du Nord à Chapel Hill, Université de São Paulo
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Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>David Geffen School of Medicine, University of California at Los Angelas (UCLA), Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Davila, Ignacio" sort="Davila, Ignacio" uniqKey="Davila I" first="Ignacio" last="Dávila">Ignacio Dávila</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital, Faculty of Medicine, University of Salamanca, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital, Faculty of Medicine, University of Salamanca, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Park, Hae Sim" sort="Park, Hae Sim" uniqKey="Park H" first="Hae-Sim" last="Park">Hae-Sim Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Hanania, Nicola A" sort="Hanania, Nicola A" uniqKey="Hanania N" first="Nicola A" last="Hanania">Nicola A. 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Bernstein</name><affiliation wicri:level="2"><nlm:affiliation>University of Cincinnati, College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Caraballo, Luis" sort="Caraballo, Luis" uniqKey="Caraballo L" first="Luis" last="Caraballo">Luis Caraballo</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunological Research, University of Cartagena, Cartagena de Indias, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Institute for Immunological Research, University of Cartagena, Cartagena de Indias</wicri:regionArea><wicri:noRegion>Cartagena de Indias</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Yoon Seok" sort="Chang, Yoon Seok" uniqKey="Chang Y" first="Yoon-Seok" last="Chang">Yoon-Seok Chang</name><affiliation wicri:level="3"><nlm:affiliation>Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chikhladze, Manana" sort="Chikhladze, Manana" uniqKey="Chikhladze M" first="Manana" last="Chikhladze">Manana Chikhladze</name><affiliation wicri:level="1"><nlm:affiliation>Medical Faculty at Akaki Tsereteli State University, KuTaisi, Tskaltubo, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Medical Faculty at Akaki Tsereteli State University, KuTaisi, Tskaltubo</wicri:regionArea><wicri:noRegion>Tskaltubo</wicri:noRegion></affiliation></author><author><name sortKey="Fiocchi, Alessandro" sort="Fiocchi, Alessandro" uniqKey="Fiocchi A" first="Alessandro" last="Fiocchi">Alessandro Fiocchi</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Department, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Allergy Department, Bambino Gesù Children's Hospital IRCCS, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Gonzalez Diaz, Sandra N" sort="Gonzalez Diaz, Sandra N" uniqKey="Gonzalez Diaz S" first="Sandra N" last="González-Diaz">Sandra N. González-Diaz</name><affiliation wicri:level="1"><nlm:affiliation>Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Universidad Autónoma de Nuevo León, Monterrey, NL</wicri:regionArea><wicri:noRegion>NL</wicri:noRegion></affiliation></author><author><name sortKey="Tanno, Luciana Kase" sort="Tanno, Luciana Kase" uniqKey="Tanno L" first="Luciana Kase" last="Tanno">Luciana Kase Tanno</name><affiliation wicri:level="3"><nlm:affiliation>Division of Allergy, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Division of Allergy, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Levin, Michael" sort="Levin, Michael" uniqKey="Levin M" first="Michael" last="Levin">Michael Levin</name><affiliation wicri:level="1"><nlm:affiliation>Division Paediatric Allergology, University of Cape Town, Cape Town, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division Paediatric Allergology, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Ortega Martell, Jose Ant Nio" sort="Ortega Martell, Jose Ant Nio" uniqKey="Ortega Martell J" first="Jose Ant Nio" last="Ortega-Martell">Jose Ant Nio Ortega-Martell</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, Autonomous University of Hidalgo State, Pachuca, Hidalgo, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>School of Medicine, Autonomous University of Hidalgo State, Pachuca, Hidalgo</wicri:regionArea><wicri:noRegion>Hidalgo</wicri:noRegion></affiliation></author><author><name sortKey="Passalacqua, Giovanni" sort="Passalacqua, Giovanni" uniqKey="Passalacqua G" first="Giovanni" last="Passalacqua">Giovanni Passalacqua</name><affiliation wicri:level="1"><nlm:affiliation>Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Peden, David B" sort="Peden, David B" uniqKey="Peden D" first="David B" last="Peden">David B. Peden</name><affiliation wicri:level="4"><nlm:affiliation>Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Rouadi, Philip W" sort="Rouadi, Philip W" uniqKey="Rouadi P" first="Philip W" last="Rouadi">Philip W. Rouadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.</nlm:affiliation><country xml:lang="fr">Liban</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author><author><name sortKey="Sublett, James L" sort="Sublett, James L" uniqKey="Sublett J" first="James L" last="Sublett">James L. Sublett</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Allergy & Immunology, University of Louisville School of Medicine, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Allergy & Immunology, University of Louisville School of Medicine, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Wong, Gary W K" sort="Wong, Gary W K" uniqKey="Wong G" first="Gary W K" last="Wong">Gary W K. Wong</name><affiliation wicri:level="4"><nlm:affiliation>Department of Paediatrics, Chinese University of Hong Kong, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Bleecker, Eugene R" sort="Bleecker, Eugene R" uniqKey="Bleecker E" first="Eugene R" last="Bleecker">Eugene R. Bleecker</name><affiliation wicri:level="2"><nlm:affiliation>Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona Health Sciences, Tucson, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32426090</idno><idno type="pmid">32426090</idno><idno type="doi">10.1016/j.waojou.2020.100126</idno><idno type="pmc">PMC7229954</idno><idno type="wicri:Area/Main/Corpus">001209</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001209</idno><idno type="wicri:Area/Main/Curation">001209</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001209</idno><idno type="wicri:Area/Main/Exploration">001209</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19, asthma, and biological therapies: What we need to know.</title><author><name sortKey="Morais Almeida, Mario" sort="Morais Almeida, Mario" uniqKey="Morais Almeida M" first="Mário" last="Morais-Almeida">Mário Morais-Almeida</name><affiliation wicri:level="1"><nlm:affiliation>Allergy Centre, CUF Descobertas Hospital, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Allergy Centre, CUF Descobertas Hospital, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Aguiar, Rita" sort="Aguiar, Rita" uniqKey="Aguiar R" first="Rita" last="Aguiar">Rita Aguiar</name><affiliation wicri:level="1"><nlm:affiliation>Allergy Centre, CUF Descobertas Hospital, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Allergy Centre, CUF Descobertas Hospital, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Bryan" sort="Martin, Bryan" uniqKey="Martin B" first="Bryan" last="Martin">Bryan Martin</name><affiliation wicri:level="2"><nlm:affiliation>The Ohio State University, Columbus, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Ansotegui, Ignacio J" sort="Ansotegui, Ignacio J" uniqKey="Ansotegui I" first="Ignacio J" last="Ansotegui">Ignacio J. Ansotegui</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Quironsalud Bizkaia, Bilbao-Erandio, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Quironsalud Bizkaia, Bilbao-Erandio</wicri:regionArea><wicri:noRegion>Bilbao-Erandio</wicri:noRegion></affiliation></author><author><name sortKey="Ebisawa, Motohiro" sort="Ebisawa, Motohiro" uniqKey="Ebisawa M" first="Motohiro" last="Ebisawa">Motohiro Ebisawa</name><affiliation wicri:level="1"><nlm:affiliation>National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagwa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagwa</wicri:regionArea><wicri:noRegion>Kanagwa</wicri:noRegion></affiliation></author><author><name sortKey="Arruda, L Karla" sort="Arruda, L Karla" uniqKey="Arruda L" first="L Karla" last="Arruda">L Karla Arruda</name><affiliation wicri:level="4"><nlm:affiliation>Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Caminati, Marco" sort="Caminati, Marco" uniqKey="Caminati M" first="Marco" last="Caminati">Marco Caminati</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University of Verona, Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Internal Medicine, University of Verona, Allergy Unit and Asthma Center, Verona University Hospital, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Canonica, Giorgio Walter" sort="Canonica, Giorgio Walter" uniqKey="Canonica G" first="Giorgio Walter" last="Canonica">Giorgio Walter Canonica</name><affiliation wicri:level="1"><nlm:affiliation>Personalized Medicine Asthma & Allergy Clinic, Humanitas University & Research Hospital IRCCS, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Personalized Medicine Asthma & Allergy Clinic, Humanitas University & Research Hospital IRCCS, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Carr, Tara" sort="Carr, Tara" uniqKey="Carr T" first="Tara" last="Carr">Tara Carr</name><affiliation wicri:level="2"><nlm:affiliation>Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Chupp, Geoffrey" sort="Chupp, Geoffrey" uniqKey="Chupp G" first="Geoffrey" last="Chupp">Geoffrey Chupp</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Corren, Jonathan" sort="Corren, Jonathan" uniqKey="Corren J" first="Jonathan" last="Corren">Jonathan Corren</name><affiliation wicri:level="2"><nlm:affiliation>David Geffen School of Medicine, University of California at Los Angelas (UCLA), Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>David Geffen School of Medicine, University of California at Los Angelas (UCLA), Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Davila, Ignacio" sort="Davila, Ignacio" uniqKey="Davila I" first="Ignacio" last="Dávila">Ignacio Dávila</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital, Faculty of Medicine, University of Salamanca, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital, Faculty of Medicine, University of Salamanca, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Park, Hae Sim" sort="Park, Hae Sim" uniqKey="Park H" first="Hae-Sim" last="Park">Hae-Sim Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Hanania, Nicola A" sort="Hanania, Nicola A" uniqKey="Hanania N" first="Nicola A" last="Hanania">Nicola A. Hanania</name><affiliation wicri:level="2"><nlm:affiliation>Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rosenwasser, Lanny" sort="Rosenwasser, Lanny" uniqKey="Rosenwasser L" first="Lanny" last="Rosenwasser">Lanny Rosenwasser</name><affiliation wicri:level="1"><nlm:affiliation>University of Missouri, Kansas City School of Medicine, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Missouri, Kansas City School of Medicine</wicri:regionArea><wicri:noRegion>Kansas City School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Borges, Mario" sort="Sanchez Borges, Mario" uniqKey="Sanchez Borges M" first="Mario" last="Sánchez-Borges">Mario Sánchez-Borges</name><affiliation wicri:level="1"><nlm:affiliation>Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.</nlm:affiliation><country xml:lang="fr">Venezuela</country><wicri:regionArea>Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas</wicri:regionArea><wicri:noRegion>Caracas</wicri:noRegion></affiliation></author><author><name sortKey="Virchow, J Christian" sort="Virchow, J Christian" uniqKey="Virchow J" first="J Christian" last="Virchow">J Christian Virchow</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology/Intensive Care Medicine, Universitätsmedizin, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pneumology/Intensive Care Medicine, Universitätsmedizin, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Ya Ez, Anahi" sort="Ya Ez, Anahi" uniqKey="Ya Ez A" first="Anahí" last="Yá Ez">Anahí Yá Ez</name><affiliation wicri:level="1"><nlm:affiliation>INAER-Investigaciones en Alergia y Enfermedades Respiratorias, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>INAER-Investigaciones en Alergia y Enfermedades Respiratorias, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Bernstein, Jonathan A" sort="Bernstein, Jonathan A" uniqKey="Bernstein J" first="Jonathan A" last="Bernstein">Jonathan A. Bernstein</name><affiliation wicri:level="2"><nlm:affiliation>University of Cincinnati, College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati, College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Caraballo, Luis" sort="Caraballo, Luis" uniqKey="Caraballo L" first="Luis" last="Caraballo">Luis Caraballo</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunological Research, University of Cartagena, Cartagena de Indias, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Institute for Immunological Research, University of Cartagena, Cartagena de Indias</wicri:regionArea><wicri:noRegion>Cartagena de Indias</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Yoon Seok" sort="Chang, Yoon Seok" uniqKey="Chang Y" first="Yoon-Seok" last="Chang">Yoon-Seok Chang</name><affiliation wicri:level="3"><nlm:affiliation>Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Chikhladze, Manana" sort="Chikhladze, Manana" uniqKey="Chikhladze M" first="Manana" last="Chikhladze">Manana Chikhladze</name><affiliation wicri:level="1"><nlm:affiliation>Medical Faculty at Akaki Tsereteli State University, KuTaisi, Tskaltubo, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Medical Faculty at Akaki Tsereteli State University, KuTaisi, Tskaltubo</wicri:regionArea><wicri:noRegion>Tskaltubo</wicri:noRegion></affiliation></author><author><name sortKey="Fiocchi, Alessandro" sort="Fiocchi, Alessandro" uniqKey="Fiocchi A" first="Alessandro" last="Fiocchi">Alessandro Fiocchi</name><affiliation wicri:level="3"><nlm:affiliation>Allergy Department, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Allergy Department, Bambino Gesù Children's Hospital IRCCS, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Gonzalez Diaz, Sandra N" sort="Gonzalez Diaz, Sandra N" uniqKey="Gonzalez Diaz S" first="Sandra N" last="González-Diaz">Sandra N. González-Diaz</name><affiliation wicri:level="1"><nlm:affiliation>Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Universidad Autónoma de Nuevo León, Monterrey, NL</wicri:regionArea><wicri:noRegion>NL</wicri:noRegion></affiliation></author><author><name sortKey="Tanno, Luciana Kase" sort="Tanno, Luciana Kase" uniqKey="Tanno L" first="Luciana Kase" last="Tanno">Luciana Kase Tanno</name><affiliation wicri:level="3"><nlm:affiliation>Division of Allergy, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Division of Allergy, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Levin, Michael" sort="Levin, Michael" uniqKey="Levin M" first="Michael" last="Levin">Michael Levin</name><affiliation wicri:level="1"><nlm:affiliation>Division Paediatric Allergology, University of Cape Town, Cape Town, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division Paediatric Allergology, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Ortega Martell, Jose Ant Nio" sort="Ortega Martell, Jose Ant Nio" uniqKey="Ortega Martell J" first="Jose Ant Nio" last="Ortega-Martell">Jose Ant Nio Ortega-Martell</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, Autonomous University of Hidalgo State, Pachuca, Hidalgo, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>School of Medicine, Autonomous University of Hidalgo State, Pachuca, Hidalgo</wicri:regionArea><wicri:noRegion>Hidalgo</wicri:noRegion></affiliation></author><author><name sortKey="Passalacqua, Giovanni" sort="Passalacqua, Giovanni" uniqKey="Passalacqua G" first="Giovanni" last="Passalacqua">Giovanni Passalacqua</name><affiliation wicri:level="1"><nlm:affiliation>Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Peden, David B" sort="Peden, David B" uniqKey="Peden D" first="David B" last="Peden">David B. Peden</name><affiliation wicri:level="4"><nlm:affiliation>Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Rouadi, Philip W" sort="Rouadi, Philip W" uniqKey="Rouadi P" first="Philip W" last="Rouadi">Philip W. Rouadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.</nlm:affiliation><country xml:lang="fr">Liban</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author><author><name sortKey="Sublett, James L" sort="Sublett, James L" uniqKey="Sublett J" first="James L" last="Sublett">James L. Sublett</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Allergy & Immunology, University of Louisville School of Medicine, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Allergy & Immunology, University of Louisville School of Medicine, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Wong, Gary W K" sort="Wong, Gary W K" uniqKey="Wong G" first="Gary W K" last="Wong">Gary W K. Wong</name><affiliation wicri:level="4"><nlm:affiliation>Department of Paediatrics, Chinese University of Hong Kong, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Bleecker, Eugene R" sort="Bleecker, Eugene R" uniqKey="Bleecker E" first="Eugene R" last="Bleecker">Eugene R. Bleecker</name><affiliation wicri:level="2"><nlm:affiliation>Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona Health Sciences, Tucson, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author></analytic><series><title level="j">The World Allergy Organization journal</title><idno type="ISSN">1939-4551</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Managing patients with severe asthma during the coronavirus pandemic and COVID-19 is a challenge. Authorities and physicians are still learning how COVID-19 affects people with underlying diseases, and severe asthma is not an exception. Unless relevant data emerge that change our understanding of the relative safety of medications indicated in patients with asthma during this pandemic, clinicians must follow the recommendations of current evidence-based guidelines for preventing loss of control and exacerbations. Also, with the absence of data that would indicate any potential harm, current advice is to continue the administration of biological therapies during the COVID-19 pandemic in patients with asthma for whom such therapies are clearly indicated and have been effective. For patients with severe asthma infected by SARS-CoV-2, the decision to maintain or postpone biological therapy until the patient recovers should be a case-by-case based decision supported by a multidisciplinary team. A registry of cases of COVID-19 in patients with severe asthma, including those treated with biologics, will help to address a clinical challenge in which we have more questions than answers.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32426090</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>27</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1939-4551</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>May</Month></PubDate></JournalIssue><Title>The World Allergy Organization journal</Title><ISOAbbreviation>World Allergy Organ J</ISOAbbreviation></Journal><ArticleTitle>COVID-19, asthma, and biological therapies: What we need to know.</ArticleTitle><Pagination><MedlinePgn>100126</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.waojou.2020.100126</ELocationID><Abstract><AbstractText>Managing patients with severe asthma during the coronavirus pandemic and COVID-19 is a challenge. Authorities and physicians are still learning how COVID-19 affects people with underlying diseases, and severe asthma is not an exception. Unless relevant data emerge that change our understanding of the relative safety of medications indicated in patients with asthma during this pandemic, clinicians must follow the recommendations of current evidence-based guidelines for preventing loss of control and exacerbations. Also, with the absence of data that would indicate any potential harm, current advice is to continue the administration of biological therapies during the COVID-19 pandemic in patients with asthma for whom such therapies are clearly indicated and have been effective. For patients with severe asthma infected by SARS-CoV-2, the decision to maintain or postpone biological therapy until the patient recovers should be a case-by-case based decision supported by a multidisciplinary team. A registry of cases of COVID-19 in patients with severe asthma, including those treated with biologics, will help to address a clinical challenge in which we have more questions than answers.</AbstractText><CopyrightInformation>© 2020 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Morais-Almeida</LastName><ForeName>Mário</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Allergy Centre, CUF Descobertas Hospital, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aguiar</LastName><ForeName>Rita</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Allergy Centre, CUF Descobertas Hospital, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Bryan</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>The Ohio State University, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ansotegui</LastName><ForeName>Ignacio J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Hospital Quironsalud Bizkaia, Bilbao-Erandio, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ebisawa</LastName><ForeName>Motohiro</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagwa, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arruda</LastName><ForeName>L Karla</ForeName><Initials>LK</Initials><AffiliationInfo><Affiliation>Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caminati</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Verona, Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canonica</LastName><ForeName>Giorgio Walter</ForeName><Initials>GW</Initials><AffiliationInfo><Affiliation>Personalized Medicine Asthma & Allergy Clinic, Humanitas University & Research Hospital IRCCS, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carr</LastName><ForeName>Tara</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chupp</LastName><ForeName>Geoffrey</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corren</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>David Geffen School of Medicine, University of California at Los Angelas (UCLA), Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dávila</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>University Hospital, Faculty of Medicine, University of Salamanca, Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Hae-Sim</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hanania</LastName><ForeName>Nicola A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosenwasser</LastName><ForeName>Lanny</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>University of Missouri, Kansas City School of Medicine, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sánchez-Borges</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Virchow</LastName><ForeName>J Christian</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Pneumology/Intensive Care Medicine, Universitätsmedizin, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yáñez</LastName><ForeName>Anahí</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INAER-Investigaciones en Alergia y Enfermedades Respiratorias, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernstein</LastName><ForeName>Jonathan A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>University of Cincinnati, College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caraballo</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute for Immunological Research, University of Cartagena, Cartagena de Indias, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Yoon-Seok</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chikhladze</LastName><ForeName>Manana</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Medical Faculty at Akaki Tsereteli State University, KuTaisi, Tskaltubo, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiocchi</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Allergy Department, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González-Diaz</LastName><ForeName>Sandra N</ForeName><Initials>SN</Initials><AffiliationInfo><Affiliation>Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanno</LastName><ForeName>Luciana Kase</ForeName><Initials>LK</Initials><AffiliationInfo><Affiliation>Division of Allergy, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levin</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division Paediatric Allergology, University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ortega-Martell</LastName><ForeName>Jose António</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>School of Medicine, Autonomous University of Hidalgo State, Pachuca, Hidalgo, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Passalacqua</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peden</LastName><ForeName>David B</ForeName><Initials>DB</Initials><AffiliationInfo><Affiliation>Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouadi</LastName><ForeName>Philip W</ForeName><Initials>PW</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sublett</LastName><ForeName>James L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Pediatric Allergy & Immunology, University of Louisville School of Medicine, Louisville, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Gary W K</ForeName><Initials>GWK</Initials><AffiliationInfo><Affiliation>Department of Paediatrics, Chinese University of Hong Kong, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bleecker</LastName><ForeName>Eugene R</ForeName><Initials>ER</Initials><AffiliationInfo><Affiliation>Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>World Allergy Organ J</MedlineTA><NlmUniqueID>101481283</NlmUniqueID><ISSNLinking>1939-4551</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AAAAI, American Academy of Allergy, Asthma and Immunology</Keyword><Keyword MajorTopicYN="N">ACAAI, American College of Allergy, Asthma and Immunology</Keyword><Keyword MajorTopicYN="N">ACE2, Angiotensin-converting 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Unit</Keyword><Keyword MajorTopicYN="N">IL13, Interleukin 13</Keyword><Keyword MajorTopicYN="N">IL4, Interleukin 4</Keyword><Keyword MajorTopicYN="N">IL5, Interleukin 5</Keyword><Keyword MajorTopicYN="N">IL5Ra, Interleukin 5 alfa receptor</Keyword><Keyword MajorTopicYN="N">IL5r, Interleukin 5 receptor</Keyword><Keyword MajorTopicYN="N">IL6, Interleukin 6</Keyword><Keyword MajorTopicYN="N">IgE, Immunoglobulin E</Keyword><Keyword MajorTopicYN="N">NHLBI, National Heart, Lung, and Blood Institute</Keyword><Keyword MajorTopicYN="N">OCS, Oral corticosteroids</Keyword><Keyword MajorTopicYN="N">PDGFRA, Platelet-Derived Growth Factor Receptor A</Keyword><Keyword MajorTopicYN="N">PROSE study, Preventative Omalizumab or Step-up therapy for fall Exacerbations study</Keyword><Keyword MajorTopicYN="N">Pandemic</Keyword><Keyword MajorTopicYN="N">RCTs, Randomized Controlled Trials</Keyword><Keyword MajorTopicYN="N">SAEs, Serious Adverse Events</Keyword><Keyword MajorTopicYN="N">SARP, Severe Asthma Research Programme</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2</Keyword><Keyword MajorTopicYN="N">SC, Subcutaneous</Keyword><Keyword MajorTopicYN="N">SIAAIC, Italian Society of Allergy, Asthma and Clinical Immunology</Keyword><Keyword MajorTopicYN="N">Severe</Keyword><Keyword MajorTopicYN="N">T2, Type 2 inflammation</Keyword><Keyword MajorTopicYN="N">TMPRSS2, Transmembrane Protease Serine 2 Enzyme</Keyword><Keyword MajorTopicYN="N">Treatment</Keyword><Keyword MajorTopicYN="N">USA, United States of America</Keyword><Keyword MajorTopicYN="N">mAb, Monoclonal antibody</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>05</Month><Day>08</Day></PubMedPubDate><PubMedPubDate 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Wong</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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